Initial therapy in patients with type 1 DM to improve glycemic control when diet & exercise do not provide adequate glycemic control. Adjunct to diet & exercise to improve glycemic control in patients with type 2 DM inadequately controlled on metformin or sitagliptin alone or in patients already being treated with the combination of sitagliptin & metformin. As part of triple combination therapy with a sulfonylurea as an adjunct to diet & exercise in patients with type 2 DM inadequately controlled with any 2 of the 23 agents: Metformin, sitagliptin or a sulfonylurea. As part of triple combination therapy with a PPARY agonist (ie, thiazolidinediones) as an adjunct to diet & exercise in patients with type 2 DM inadequately controlled with any 2 of the 3 agents: Metformin, sitagliptin or a PPRAY agonist. In combination with insulin as an adjunct to diet & exercise to improve glycemic control in patients with type 2 DM.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

Individualized dosage. Total daily starting dose: 1 tab once daily. May be titrated gradually to reduce GI effects associated with metformin, up to max of metformin 2,000 mg daily. Patient inadequately controlled on metformin monotherapy Total daily starting dose: Sitagliptin 100 mg + previously prescribed dose of metformin. Patient inadequately controlled on sitagliptin monotherapy Initially 1 tab. Metformin dose may be titrated as needed. Consider gradual dose escalation to reduce GI effects associated with metformin.

Should be taken with food: take with meals preferably in the evening. Swallow whole, do not split/break/crush/chew.