Hypertension: As monotherapy or in combination with other antihypertensive agents Pediatric hypertension Angina pectoris: Long-term prophylaxis Cardiac arrhythmias: Disturbances of cardiac rhythm, including supraventricular tachycardia, reduction of ventricular rate in atrial fibrillation and ventricular extrasystoles Myocardial infarction (MI): Maintenance treatment after MI Functional heart disorders with palpitations Hyperthyroidism Prophylaxis of migraine headache

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

Oral- Hypertension: Total daily dosage Cardiosel-OD 100-400 mg to be given as a single or twice daily dose. The starting dose is 100 mg (two Cardiosel-OD-50 tablets) per day. This may be increased by 100 mg per day at weekly intervals. lf full control is not achieved using a single daily dose, a b.i.d. regimen should be initiated. Combination therapy with a diuretic or other anti-hypertensive agent may also be considered. Angina: Usually Cardiosel-OD 50 mg (one Cardiosel-OD-50 tablet) to 100 mg (two Cardiosel-OD-50 tablets)twice or three times daily. Cardiac arrhythmias: Cardiosel-OD 50 mg (one Cardiosel-OD-50 tablet) b.i.d or t.i.d should usually control the condition. It necessary the dose can be increased up to 300 mg per day in divided doses. Following the treatment of an acute arrhythmia with Cardiosel-OD injection, continuationtherapy with Cardiosel-OD tablets should be initiated 4-6 hours later. The initial oral dose should not exceed 50 mg t.i.d. Hyperthyroidism: Cardiosel-OD 50 mg (one Cardiosel-OD-50 tablet) four times a day.The dose should bereduced as the euthyroid state is achieved. Myocardial infarction: Orally, therapy should commence 15 minutes after the last injection with50 mg every 6 hours for 48 hours. Patients who fail to tolerate the full intravenous dose should begiven half the suggested oral dose. Maintenance – The usual maintenance dose is 200 mg dailygiven in divided doses. Elderly’ There are no special dosage requirements in otherwise healthyelderly patients. Signidcant hepatic dysfunction: A reduction in dosage may be necessary. Injection- Arrhythmias: By intravenous injection, up to 5 mg at a rate of 1-2 mg/minute, repeated after 5 minutes if necessary, total dose 10-15 mg. In surgery: By slow intravenous injection 2-4 mg at induction or to control arrhythmias developing during anaesthesia; 2 mg doses may be repeated to a maximum of 10 mg. Myocardial Infarction: Early intervention within 12 hours of infarction, by intravenous injection 5 mg every 2 minutes to a maximum of 15 mg, followed after 15 minutes by 50 mg by mouth every 6 hours for 48 hours; maintenance 200 mg daily in divided doses. Impaired Renal Function: Dose adjustment is not needed in patients with impaired renal function. Impaired Hepatic Function: Dose adjustment is not normally needed in patients suffering from liver cirrhosis because Cardiosel-OD has low protein binding (5-10%). When there are signs of serious impairment of liver function (e.g. shunt-operated patients), a reduction in dose should be considered. Elderly: Dose adjustment is not needed.

Should be taken with food.