Indication*

Intramuscular, Intravenous (Diabetic Gastric Stasis). (Prophylaxis of Postoperative Nausea and Vomiting). ( Nausea and Vomiting, Prophylaxis of Nausea and Vomiting Associated with Radiation Therapy). Intravenous (Prophylaxis of delayed chemotherapy-induced Nausea and Vomiting). (Prophylaxis of Chemotherapy-Induced Nausea and Vomiting). (Postoperative Nausea and Vomiting). (Intubation of the Small Intestine, Premedication for Radiologic examination of the Upper Gastrointestinal Tract). Nasal (Diabetic Gastric Stasis). Oral (Nausea and Vomiting, Prophylaxis of Nausea and Vomiting Associated with Radiation Therapy). Oral (Gastro-Oesophageal Reflux Disease). Oral (Diabetic Gastric Stasis). (Prophylaxis of delayed Chemotherapy-Induced Nausea and Vomiting). (Intubation of the Small Intestine, Premedication for Radiologic Examination of the Upper Gastrointestinal Tract).

Directions for Use*

Intramuscular, Intravenous(Diabetic Gastric Stasis) Adult: Severe cases: 10 mg via slow IV inj over 1-2 minutes or IM inj to 10 days and may shift to oral therapy once possible. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). (Prophylaxis of Postoperative Nausea and Vomiting) Adult: 10 mg as single dose via slow IV inj over at least 3 minutes or IM inj. Treatment and dosage recommendation may vary among individual products and between countries (refer to specific product guidelines). Elderly: Dose reduction may be needed. Intramuscular, Intravenous (Nausea and Vomiting, prophylaxis of Nausea and Vomiting associated with radiation therapy) Adult: 10 mg up to tid via slow IV inj over at least 3 minutes or IM inj. Max: 30 mg daily or 0.5 mg/kg daily. Dosing interval: >6hours. Treatment and dosing recommendations may vary among individual product and between countries (refer to specific product guidelines). Elderly: Dose reduction may be needed. Intravenous (Prophylaxis of delayed Chemotherapy-Induced Nausea and Vomiting) Child: As a 2nd-line option: 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-20 kg; 9-18 years 30-60 kg: 5 mg; 15-18 years >60 kg: 10 mg. All dose to be given up to tid and via slow IV push over at least 3 minutes. Dosing interval: >6hours. Max: 0.5 mg/kg in 24 hours. Max treatment duration: 5 days. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). (Prophylaxis of Chemotherapy-Induced Nausea and Vomiting) Adult: Loading dose:2-4 mg/kg via continuous infusion over 15-20 minutes, given before cancer therapy. Maintenance: 3-5 mg/kg via continuous infusion over 8-12 hours. Alternatively, initial dose of up to 2mg /kg via intermittent infusion over at least 15 minutes, may be given before cancer therapy and repeated at 2-hourly intervals. Max total dose: 10 mg/kg in 24 hours. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Elderly: Dose reduction may be needed. (Postoperative Nausea and Vomiting) Child: As a 2nd-line option: 1-3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30-60 kg: 5 mg; 15-18 years >60 kg: 10 mg. All doses to be given up to tis and via slow IV push over at least 3 minutes. Dosing interval: >6hours. Max: 0.5 mg/kg in 24 hours. Max treatment duration: 48 hours. treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). (Intubation of the small Intestine, Premedication for Radiologic examination of the upper Gastrointestinal tract). Adult: 10 mg as single dose, given over 1-2 minutes. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: <6 years 0.2 mg/kg; 6-14 years 2.5-5 mg;> 14 years Same as adult dose. All dose to be given as single dose over 1-2 minutes. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Nasal (Diabetic Gastric Stasis) Adult: 1 spray (15 mg) in 1 nostril 4 times daily (30 minutes before each meal and at bedtime) for 2-8 weeks according to symptomatic response. Max: 4 sprays (60 mg) daily. Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines). Elderly: >65 years Not recommended for initial therapy. Oral (Nausea and Vomiting, Prophylaxis of Nausea and Vomiting associated with radiation therapy) Adult: 10 mg up to tid. Max: 30 mg daily or 0.5 mg/kg daily. Max treatment duration: 5 days. Dosing interval: >6 hours. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Elderly: Dose reduction may be needed. Oral (Gastro-0esophageal Reflux disease) Adult: In patients who fail to respond to conventional therapy: 10-15 mg 4 times daily given 30 minutes before each meal and at bedtime for 4-12 weeks, depending on endoscopic response. Max: 60 mg daily. If the occurence of symptoms is intermittent or at specific times of the day, doses up to 20 mg may be given as a single dose prior to provoking situation. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Elderly: Initially, 5mg 4 times daily given 30 minutes before each meal and at bedtime, then titrate to 10-15 mg 4 times daily according to response and tolerability. Max: 60 mg daily. (Diabetic Gastric Stasis) Adult: For acute and recurrent cases: 10 mg 4 times daily given 30 minutes before each meal and at bedtime for 2-8 weeks according to response. Max: 40 mg daily. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific products guidelines). Elderly: Initially, 5 mg 4 times daily given 30 minutes before each meal and at bedtime, then titrate to 10 mg 4 times daily according to response and tolerability. Max: 40 mg daily. (Prophylaxis of delayed Chemotherapy-induced Nausea and Vomiting) Adult: 10 mg up to tid. Max:30 mg daily or 0.5 mg/kg daily. Max treatment duration: 5 days. Dosing interval: >6 hours. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Elderly: Dose reduction may be needed. Child: As a 2nd-line option: 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. All doses to be given up to tid. Dosing interval: >6 hours. Max: 0.5 mg/kg in 24 hours. Max treatment duration: 5 days. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). (Intubation of the small intestine, Premedication for radiologic examination of the upper gastrointestinal tract) Adult: 10-20 mg as a single dose given 5-10 minutes before examination. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: 15-19 years 10 mg as a single dose given 5-10 minutes before examination.

Administration*

Should be taken with on an empty stomach. Take 30 minutes before meals. Diabetic Gastric Stasis: (Child-Pugh class or C) 5 mg 4 times daily given 30 minutes before each meal and at bedtime or 10 mg tid. Max: 20 mg daily. Gerd: Moderate or Severe (Child-Pugh class B or C): 5 mg times daily given 30 minutes before each meal and at bedtime or 10 mg tid. Max: 30 mg daily.

*written indications, directions, and administration are updated as of April 07, 2024 and may not be accurate with the actual product purchased. Please read the details in the packaging.