HTN, alone or in combination with other antihypertensive including diuretics. Decreases risk of CV morbidity & mortality in hypertensive patients with left ventricular hypertrophy. Heart failure in patients who cannot tolerate an ACE inhibitor. Diabetic nephropathy with elevated serum creatinine & proteinuria (urinary albumin to creatine ratio >300 mg/g) in patients with type 2 diabetes & history of HTN.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

Individualized dosage. HTN Adult Usual initial & maintenance dose: 50 mg once daily, may be increased to 100 mg once daily. Patient with intravascular vol-depletion (eg, those treated with high-dose diuretics) & history of liver disease Initially 25 mg once daily. Patient with moderate to severe renal disease & those on dialysis 25mg once daily. Children >6 year weighing >50 kg 50 mg daily. Max: 100 mg daily, >20- <50 kg 25 mg daily. Max: 50 mg daily. Hypertensive patient with left ventricular hypertrophy Initially 50 mg once daily. Add hydrochlorothiazide 12.5 mg daily & or increase dose to 100 mg once daily followed by increase in hydrochlorothiazide to 25 mg once daily based on BP response. Heart failure Initially 12.5 mg once daily, titrated at weekly intervals (ie,12.5 mg daily, 25 mg daily, 50 mg daily) to usual maintenance dose of 50 mg once daily as tolerated. Nephropathy in type 2 diabetic patient Initially 50 mg once daily, may be increased to 100 mg once daily.

May be taken with or without food.