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GLIMEPIRIDE

NORIZEC 1MG TABLET

1mg Tablet

Indication*

Adjunct to proper dietary management, physical exercise and weight reduction to improve glycemic control in adults with type 2 diabetes mellitus. Glimepiride may be used as monotherapy or in combination with metformin or insulin.

Directions for Use*

There is usual no fixed dosage regimen with any antidiabetic agent for the management of hyperglycemia in patients with diabetes mellitus. Dosage should be individualized based on both effectiveness and patient tolerance. Inform patients on the potential risks and advantages of glimepiride and alternative modes of therapy. The importance of adherence to dietary instructions, regular exercise program and regular testing of blood glucose should also be advised to patients. During treatment initiation and dose titration, fasting plasma glucose (FPG) should be used to identify the minimum effective dose and determine the therapeutic response to glimepiride (i.e,. detect primary and secondary failure). Glycosylated hemoglobin (HbA1c) should be measured at intervals of approximately every three months to monitor patient's response to therapy. Short-term administration of glimepiride may be sufficient during periods of transient loss of control in patients usually controlled well on diet and exercise. Usual Starting Dose: As initial therapy: 1-2 mg once daily with breakfast or the first main meal. Start patients who may be more sensitive to hypoglycemic agents at 1 mg once daily and titrate dose carefully. No exact dosage relationship exists between glimepiride and other oral hypoglycemic agents. Maximum Starting Dose: not more than 2 mg. Failure to follow an appropriate drug regimen may precipitate hypoglycemia. Patients who do not adhere to their prescribed dietary and drug regimen are more prone to exhibit unsatisfactory response to therapy. Usual Maintenance Dose: 1-4 mg once daily. Maximum Recommended Dose: 8 mg once daily. After reaching a dose of 2 mg, increase dosage in increments of not more than 2 mg at 1-2 week intervals based on the patient's glucose response. Glimepiride-Metformin Combination Therapy: If patients do not respond adequately to the maximum dose of glimepiride monotherapy, consider addition of metformin. Glycemic control may be obtained by adjusting the dose the dose of each drug. Identify the minimum affective dose of each drug to achieve this goal. The risk oh hypoglycemia associated with glimepiride may be increased with concomitant metformin therapy. Undertake necessary precautions. Glimepiride-Insulin Combination Therapy: Combination therapy with glimepirde and insulin may also be used in patients with secondary failure. The fasting glucose level for instituting combination therapy is in the range of >150 mg/dL in plasma or serum. Recommended Glimepiride Dose: 8 mg once daily with the first main meal. Start with low dose insulin and adjust weekly, guided by frequent FPG monitoring. Once stable, patients on combination therapy should monitor their capillary blood glucose, preferably on a daily basis. Periodic adjustments of insulin may be necessary during maintenance as guided by glucose Or, as prescribed by a physician.

Administration*

Should be taken with food. Take immediately before the 1st main meal of the day. Do not skip meals.

*written indications, directions, and administration are updated as of February 21, 2024 and may not be accurate with the actual product purchased. Please read the details in the packaging.

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