Treatment of HTN & heart failure. Prophylaxis to patients with asymptomatic left ventricular dysfunction to delay the onset of symptomatic heart failure & those with left ventricular dysfunction to reduce the incidence of coronary ischemic events, including MI.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

HTN Initially 5mg/day. Usually 10-40 mg/day as a single or 2 divided doses. Renal impairment CrCI <30 mL/min (serum creatine >3mg/dL) 2.5mg once daily on the 1st dose. Then may titrate dose upward until BP is controlled. Max: >0.58 mg/kg (or >40mg). Heart failure Initially 2.5 mg/day. Maintenance: 20 mg/day as a single dose or in 2 divided doses. Asymptomatic left ventricular dysfunction Initially, 2.5mg bid. Titrate as tolerated to the targeted daily dose of 20 mg in divided doses. Renal impairment (serum creatinine >1.6 mg/dL) or hyponatremia (serum Na <130 mEq/L) Initially at 2.5 mg daily. May increase dose to 2.5 bid, then 5mg bid & higher as needed, usually at intervals of 4 days or more. Max daily dose: 40mg.

Should be taken with food: Take with food or immediately after meals.