DIGOXIN
DIXIN
250mcg Tablet
Indication*
Digoxin is used in the management of supraventricular arrhythmias, particularly atrial fibrillation, and in heart failure. Cardiac arrhythmias. In atrial arrhythmias digoxin's action cause a decrease in the conduction velocity through the AV node and increase in the effective refractory period, thus reducing ventricular rate. Digoxin is thus given to slow the increased ventricular rate that occurs in response to atrial fibrillation. In atrial flutter, the ventricular rate that occurs in response to atrial fibrillation. In atrial flutter, the ventricular rate is normally more difficult to control with digoxin. Heart failure. Digoxin directly inhibit the activity of the enzyme sodium-potassium adenosine triphosphatase (Na/K-ATPase,), which is required for the active transport of sodium from myocardial cells. When used in heart failure the increased force of myocardial contraction results in increased cardiac output, decreased end-systolic volume, decreased heart size, and decreased end-diastolic pressure and volume.
Directions for Use*
Administration*
Dosage should be carefully adjusted to the needs of the individual patient. Factors which may be considered include the patient's age, lean body-mass, renal status, thyroid status, electrolyte balance, degree of tissue oxygenation, and the nature of the underlying cardiac or pulmonary disease. The usual maintenance dose of digoxin is 125 to 250 micrograms by mouth daily, but may range from 62.5 to 500 micrograms daily. In elderly patients therapy should generally be initiated gradually and with smaller doses. Doses should be reduced in patients with renal impairment. Or as prescribed by a physician.
*written indications, directions, and administration are updated as of January 28, 2024 and may not be accurate with the actual product purchased. Please read the details in the packaging.
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