Recent MI or Stroke, or established peripheral arterial disease: Recommended Dose: Orally, 75 mg once daily with or without food. prophylaxis of thromboembolic event: Usual dose: Orally, 75 mg once daily. Non-ST segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI): Initiate a single 300 mg loading dose and then continue at 75 mg once daily in combination with aspirin. A higher bleeding risk was associated with combined use of clopidogrel and aspirin. It is recommended that physicians monitor their patients through clinical and laboratory evaluation. Or, as prescribed by a physician.