In adults for the symptomatic relief in the treatment of: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. The decision to prescribe a selective cyclooxygenase-2 (COX-2) inhibitor should be based on an assessment of the individual patient's overall risks.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

OA 200 mg once daily or in 2 divided doses, may be increased to 200 mg bid. RA Initially 200 mg in 2 divided doses, may be increased to 200 mg bid, Ankylosing spondylitis 200 mg once daily or in 2 divided doses, may be increased to 400 mg once daily or in 2 divided doses. All indications Max daily dose: 400 mg. Elderly >65 year Initially 200 mg daily, may be increased to 200 mg bid. Moderate hepatic impairment (serum albumin 25-35 g/L) Initially 1/2 the recommended dose. CYP2C09 poor metabolisers Consider reducing dose to 1/2 of lowest recommended dose.

May be taken with or without food: For patients with difficulty swallowing, entire cap contents may be carefully emptied onto level tsp of cool or room temp applesauce, rice gruel, yogurt or mashed banana & should be ingested immediately with glass of water.