Prevention of VTE in adults who have undergone elective hip or knee replacement surgery. Reduces the risk of stroke, systemic embolism, & death in patients with nonvalvular atrial fibrillation (NVAF) with >1 risk factors, including patients unsuitable for warfarin. Treatment & prevention of recurrent DVT & pulmonary embolism (PE).

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Prevention of VTE in elective hip or knee replacement surgery. Prevention of stroke & systemic embolism in patient with NVAF 5mg bid. Patient with at least 2 of the following characteristic: >80 year, <60 kg, or serum creatinine >1.5 mg/dL (133 mmoI/L) 2.5mg bid. DVT & PE 10mg bid for 7 days, followed by 5mg bid. Prevention of recurrent DVT & PE 2.5mg bid after at least 6 mth of treatment for DVT or PE. Surgery & invasive procedures for patient not previously treated with anticoagulants At least 5 doses of 5mg bid (2.5mg bid in patient who quality for dose reduction) should be given before cardioversion to ensure adequate anticoagulation. If cardioversion is required before 5 doses of Apixaban: 10mg loading dose, followed by 5mg bid. Reduce to 5mg loading dose, followed by 2.5mg bid if the patients meets the criteria for dose reduction. Loading dose should be given at least 2 hour before cardioversion.

May be taken with or without food: For patients with difficulty swallowing , crush tab & suspend in water /5% dextrose in water(D5W) apple juice or mix with applesauce & drink immediately. Alternatively, crush tab & suspend in 60mL water/D5W & administer immediately via nasogastric tube.