Hydrochlorothiazide is used in the treatment of edema associated with heart failure and with renal and hepatic disorders. It is also used in the treatment of hypertension, either alone or together with other antihypertensives such as ACE inhibitors and beta blockers. Hydrochlorothiazide is also indicated in the treatment of edema accompanying premenstrual syndrome, prevention of water retention associated with corticosteroids and estrogens, treatment of diabetes insipidus, and prevention of renal calculus formation in patients with hypercalciuria.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

Doses are usually given in the morning so that sleep is not interrupted by diuresis. Diuresis is initiated in about 4 hours following the oral administration of hydrochlorothiazide is given orally. In the treatment of edema, the usual dose is 25 mg to 100 mg daily, reduced to a dose of 25 mg to 50 mg daily or intermittently; in severe cases, initial dose up to 200 mg daily have been suggested. In the treatment of nephrogenic diabetes insipidus, an initial dose of up to 100mg daily may be employed. In the treatment of hypertension, the usual dose of hydrochlorothiazide is 25 mg to 50 mg daily, either alone or in conjunction with other anti-hypertensives. In some patients an initial dose of 12.5mg may be sufficient. Dose up to 100 mg have been suggested but use rarely.

Should be taken with food.