Management of essential HTN alone or in combination with other antihypertensive. Mild to severe chronic heart failure of ischemic or cardiomyophatic origin in combination with diuretics, ACE inhibitors, & digitalis to increase survival & decrease risk of hospitalizations. Decreases CV mortality in clinically stable patients who have survived acute phase of MI & have a left ventricular ejection fraction of >40% (with or without symptomatic heart failure). Prophylactic treatment of stable angina.

This is not a substitute for consulting your doctor. Seek professional advice if you are experiencing any illness or symptoms.

HTN Initially 12.5 mg once daily or 6.25 mg bid. Thereafter, recommended dose is 25 mg once daily or 12.5 mg bid. Dose may be increased at intervals of at least 2 week to max of 50 mg given once daily or in divided doses (bid). Angina pectoris Adults Initially 12.5 mg bid for the 1st 2 days. Thereafter, recommended dose is 25 mg bid. Dose may be increased at intervals of at least 2 week to max of 100 mg in divided doses (bid). Elderly 50 mg in divided doses (bid). Symptomatic, stable chronic heart failure Initially 3.125 mg bid for 2 week, If dose is tolerated, increase to 6.25 mg bid, followed by 12.5 mg bid & thereafter 25mg bid, at intervals of not <2 week. Max: 25 mg bid, followed by 12.5 mg bid& thereafter 25 mg bid, at intervals of not <2 week. Max: 25 mg bid in patient with severe heart failure & with mild to moderate heart failure <85kg, or 50 mg bid in patient with mild to moderate heart failure & with mild to moderate heart failure >85 kg. Left ventricular dysfunction following MI 1st dose: Initially 6.25 mg, increased to 6.25 mg bid & maintained for 3-10 days. Decrease dose to 3.125 mg bid if patient develops signs of tolerance. If well tolerated, increase dose to 6.25 mg bid after 3-10 days & if further well tolerance. If well tolerated, increase dose to 6.25mg bid after 3-10 days & if further well tolerated , increase dose at intervals of 3-10 days to 12.5 mg bid & then 25 mg bid. Max: 25 mg bid.

Should be taken with food: Take with food to slow rate of absorption & reduce incidence of orthostatic effects.