Prevention of VTE in adults who have undergone elective hip or knee replacement surgery. Reduced the risk of stroke, systemic embolism, & death in patients with nonvalvular atrial fibrillation (NVAF) with >1 risk factors, including patients unsuitable for warfarin. Treatment & prevention (recurrent ) of DVT & pulmonary embolism (PE).

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Prevention of VTE in elective hip or knee replacement surgery 2.5mg bid. Initial dose should be taken 12-24 hour after surgery. Recommended duration of treatment: 32-38 days for hip replacement surgery. Prevention of stroke & systemic embolism Patient with NVAF 5mg bid. Patient with at least 2 of the following characteristics: >80 year, <60kg, or serum creatinine >1.5mg/dL (133 mmoI/L) 2.5mg bid. DVT & PE 10mg bid for days, followed by 5mg bid. Prevention of recurrent DVT & PE 2.5mg bid after at least 6 month of treatment for DVT or PE. Surgery & invasive procedures Patients not previously treated with anticoagulants At least 5 doses of 5 mg bid (2.5mg bid in patient who quality for dose reduction) should be given before cardioversion to ensure adequate anticoagulation. If cardioversion is required before 5 doses of Eliquis: 10mg loading dose, followed by 5 mf bid. Reduce to 5mg loading dose, followed by 2.5mg bid if the patients meets the criteria for dose reduction. Loading dose should be given at least 2 hour before cardioversion.

May be taken with or without food: For patients with swallowing difficulties, crush tab & suspend in water , 5% dextrose in water (D5W), apple juice or mixed with applesauce. Drink immediately. SoIn stable for 4 hour. Alternatively, crush & suspend in 60 mL water or D5W & administer via nasogastric tube.